EARLYDRAIN: Study Protocol for Early Lumbar CSF Drainage in Aneurysmal Subarachnoid Hemorrhage
Author Information
Author(s): Jürgen Bardutzky, Jens Witsch, Eric Jüttler, Stefan Schwab, Peter Vajkoczy, Stefan Wolf
Primary Institution: Charité Center for Stroke Research Berlin
Hypothesis
Early application of a lumbar drain after aneurysmal SAH leads to an improved outcome at six months after the hemorrhage.
Conclusion
The EARLYDRAIN study aims to determine if early lumbar drainage improves clinical outcomes in patients with aneurysmal subarachnoid hemorrhage.
Supporting Evidence
- Retrospective studies suggest lumbar drainage may reduce the incidence of delayed cerebral ischemia.
- Previous studies indicated a lower mortality rate in patients receiving lumbar drainage.
- The study design follows ethical guidelines and has received ethical approval.
Takeaway
This study is trying to find out if putting a drain in the back of patients with a certain type of brain bleed can help them get better after six months.
Methodology
A 2-arm randomized controlled trial comparing early continuous lumbar CSF drainage plus standard care to standard care alone.
Potential Biases
Potential biases may arise from the subjective assessment of outcomes and the variability in treatment protocols across centers.
Limitations
The study may face challenges in recruitment and adherence to the protocol due to the critical condition of patients.
Participant Demographics
Adults aged 18 and older with a first aneurysmal subarachnoid hemorrhage.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website