Genetics of Recurrent Vertigo and Vestibular Disorders
Author Information
Author(s): Gazquez Irene, Lopez-Escamez Jose A
Primary Institution: Centro de Genómica e Investigación Oncológica –GENyO Pfizer-Universidad de Granada- Junta de Andalucia, Granada
Hypothesis
The genetics of vestibulopathies is largely not known despite several vestibular disorders being more common within families.
Conclusion
Recent advances in genetics have improved the understanding of recurrent vertigo and its associated disorders.
Supporting Evidence
- Familial episodic ataxias are rare causes of recurrent vertigo, with identified mutations in KCNA1 and CACNA1A genes.
- Migraine has a strong genetic background and is frequently observed in patients with vestibular disorders.
- Meniere’s disease is characterized by recurrent vertigo and has a familial component in 10-20% of cases.
Takeaway
This study looks at how genetics can affect balance problems and dizziness, which can run in families.
Methodology
The study reviews genetic findings related to various vestibular disorders and discusses ongoing collaborative efforts for genome-wide association studies.
Limitations
The genetic basis of many vestibular disorders remains poorly defined, and the study relies on existing literature and ongoing research.
Digital Object Identifier (DOI)
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