Lower Bone Density Linked to Fractures in Young Girls
Author Information
Author(s): Farr Joshua N, Tomás Rita, Chen Zhao, Lisse Jeffrey R, Lohman Timothy G, Going Scott B
Primary Institution: University of Arizona
Hypothesis
Is there a relationship between prior fractures and bone parameters in young girls?
Conclusion
Fractures in girls are associated with lower trabecular volumetric bone mineral density at metaphyseal sites of the femur and tibia.
Supporting Evidence
- Lower trabecular vBMD at metaphyseal sites was significantly associated with prior fractures.
- Every SD decrease in trabecular vBMD at metaphyseal sites was linked to higher fracture prevalence.
- Fractures were not associated with metaphyseal bone size.
Takeaway
Girls who have broken bones tend to have weaker bones in certain areas, which might mean they are more likely to break bones again in the future.
Methodology
The study analyzed bone parameters using pQCT and DXA in 465 girls aged 8 to 13 years, comparing those with and without prior fractures.
Potential Biases
Potential misreporting of fractures and variability in timing of bone measurements post-fracture.
Limitations
The study is cross-sectional, which limits causal inferences, and relies on self-reported fracture history.
Participant Demographics
465 healthy girls aged 8 to 13 years, 22% Hispanic, 78% non-Hispanic, with a mix of Tanner stages.
Statistical Information
P-Value
p<0.05
Confidence Interval
1.1–1.9 for femur, 1.0–1.7 for tibia
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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