Marrow Changes After Chemotherapy in Lymphoma
Author Information
Author(s): Tang Bingfeng, Patel Malaykumar M., Wong Regina H., Wood Daniel, Wong Christiana O., Wu Dafang, Khong Pek Lan, Wong Ching Yee Oliver
Primary Institution: The Ohio State University College of Medicine
Hypothesis
Can individual marrow metabolic changes after chemotherapy be correlated with bone marrow biopsy results for personalized care in lymphoma?
Conclusion
The study found a strong correlation between marrow metabolic changes after chemotherapy and bone marrow involvement proven by biopsy.
Supporting Evidence
- 12 of 35 biopsy sites were positive with a decrease in SUV in 11 of those sites.
- 23 of 35 biopsy sites were negative with an increase in SUV in 21 of those sites.
- The correlation between SUV change and biopsy results was significant.
Takeaway
This study looked at how chemotherapy affects the bone marrow in lymphoma patients and found that changes in metabolism can help doctors decide on treatment.
Methodology
The study retrospectively analyzed 26 patients with lymphoma who underwent FDG-PET/CT imaging and bone marrow biopsy before chemotherapy.
Limitations
The study had a small sample size and mixed histopathological classifications.
Participant Demographics
Mean age 58 years, 13 females and 13 males.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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