No link between SLC11A1 gene and visceral leishmaniasis in India
Author Information
Author(s): Sanjana Mehrotra, Joyce Oommen, Anshuman Mishra, Medhavi Sudharshan, Puja Tiwary, Sarra E Jamieson, Michaela Fakiola, Deepa Selvi Rani, Kumarasamy Thangaraj, Madhukar Rai, Shyam Sundar, Jenefer M Blackwell
Primary Institution: Institute of Medical Sciences, Banaras Hindu University
Hypothesis
Does the SLC11A1 gene influence susceptibility to visceral leishmaniasis in India?
Conclusion
The study found no evidence that the SLC11A1 gene plays a major role in regulating susceptibility to visceral leishmaniasis in India.
Supporting Evidence
- The study genotyped nine polymorphisms associated with SLC11A1 in a large sample.
- No significant associations were found between SLC11A1 variants and visceral leishmaniasis.
- The research included both family-based and population-based analyses.
Takeaway
The researchers looked at a gene to see if it made people more likely to get a disease called visceral leishmaniasis, but they found out it doesn't really matter.
Methodology
The study involved genotyping nine polymorphisms in a primary family-based sample and a replication population-based sample to assess associations with visceral leishmaniasis.
Limitations
The study may not account for all genetic variations and environmental factors influencing disease susceptibility.
Participant Demographics
The study included 958 cases and 1015 controls, matched for age, sex, religion, caste, and geographic district.
Digital Object Identifier (DOI)
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