Viral Determinants of FeLV Infection and Pathogenesis
Author Information
Author(s): Bolin Lisa L., Levy Laura S.
Primary Institution: Tulane University
Hypothesis
What are the viral determinants that influence the pathogenesis of feline leukemia virus (FeLV) infection?
Conclusion
The study identifies unique viral isolates associated with different types of lymphomas in naturally infected cats and highlights the role of specific viral genetic elements in disease outcomes.
Supporting Evidence
- FeLV-induced malignancy is a multistep process involving both viral and host determinants.
- Unique viral isolates were associated with distinct lymphoma types in the cohort.
- LTR and SU sequences of FeLV-945 were identified as major determinants of disease outcome.
Takeaway
This study looked at sick cats to understand how a virus makes them sick, finding that different versions of the virus can cause different types of illnesses.
Methodology
Detailed analysis of tissues from a cohort of naturally infected cats over several years, including molecular analysis and experimental systems.
Limitations
Manipulation of the cat model experimentally is hampered by unpredictability and prolonged latency to malignant disease.
Participant Demographics
Cohort included 66 cats from a single veterinary practice in Pasadena, California, collected over six years.
Digital Object Identifier (DOI)
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