Lymphangiogenesis in Non-Small Cell Lung Cancer
Author Information
Author(s): Sun Jian-guo, Wang Yan, Chen Zheng-tang, Zhuo Wen-lei, Zhu Bo, Liao Rong-xia, Zhang Shao-xiang
Primary Institution: Cancer Institute of People's Liberation Army, Xinqiao Hospital, Third Military Medical University
Hypothesis
The study aims to detect lymphatic endothelial markers and assess the prognostic relevance of lymphangiogenesis in non-small cell lung cancer (NSCLC).
Conclusion
Podoplanin positive peritumoral lymphatic vessel density (ptLVD) is associated with poor prognosis in NSCLC patients.
Supporting Evidence
- High podoplanin positive ptLVD is associated with lymphatic metastasis.
- Patients with high podoplanin+ ptLVD have a poor prognosis.
- ptLVD, pathologic stage, lymph-node metastasis, and Ki67% are independent prognostic parameters for overall survival.
Takeaway
This study found that more lymphatic vessels around tumors can mean a worse outcome for lung cancer patients.
Methodology
The study analyzed 82 paraffin-embedded and 40 fresh frozen NSCLC tissues using immunohistochemical staining for lymphatic endothelial markers.
Limitations
The study is retrospective and based on a relatively small sample size.
Participant Demographics
Patients with NSCLC who underwent lobectomy or pneumonectomy between 1995 and 2004.
Statistical Information
P-Value
0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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