Effects of Coffee on Diabetes Risk Factors
Author Information
Author(s): Wedick Nicole M, Brennan Aoife M, Sun Qi, Hu Frank B, Mantzoros Christos S, van Dam Rob M
Primary Institution: Harvard School of Public Health
Hypothesis
What are the effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes?
Conclusion
Caffeinated coffee increased adiponectin and interleukin-6 levels, while decaffeinated coffee decreased fetuin-A levels, but no significant changes in glucose metabolism were observed.
Supporting Evidence
- Caffeinated coffee increased adiponectin levels by 1.4 μg/mL.
- Decaffeinated coffee decreased fetuin-A levels by 20%.
- IL-6 levels increased by 60% with caffeinated coffee.
- No significant differences in glucose metabolism were found.
Takeaway
Drinking coffee might help your body in some ways, but it doesn't seem to change how your body handles sugar.
Methodology
Randomized controlled trial with 45 healthy overweight volunteers consuming different types of coffee for 8 weeks.
Potential Biases
Potential bias due to the nature of the intervention not allowing complete blinding.
Limitations
The study had a modest sample size and participants were not completely blinded to their coffee treatment.
Participant Demographics
Healthy overweight volunteers, average age 40 years, BMI 29.5 kg/m2.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI: 0.2, 2.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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