Growth Hormone Receptor Disruption and Calorie Restriction Effects on Insulin Action and Longevity
Author Information
Author(s): Bonkowski Michael S., Dominici Fernando P., Arum Oge, Rocha Juliana S., Al Regaiey Khalid A., Westbrook Reyhan, Spong Adam, Panici Jacob, Masternak Michal M., Kopchick John J., Bartke Andrzej
Primary Institution: Southern Illinois University School of Medicine
Hypothesis
Does the GHRKO mutation modulate or completely ablate the benefits of calorie restriction on lifespan?
Conclusion
Calorie restriction increases lifespan in normal mice but does not extend lifespan in GHRKO mice due to their GH resistance.
Supporting Evidence
- Calorie restriction increased median lifespan in normal mice by 16%.
- GHRKO mice did not show increased lifespan with calorie restriction.
- Insulin sensitivity improved in normal mice but not in GHRKO mice after calorie restriction.
- Chronic calorie restriction did not further modify insulin signaling in GHRKO mice.
Takeaway
This study found that normal mice live longer with less food, but mice with a specific mutation that makes them resistant to growth hormone don't benefit from this diet.
Methodology
The study involved long-term calorie restriction in normal and GHRKO mice, measuring their lifespan and insulin signaling responses.
Limitations
The study primarily focused on male mice, which may limit the generalizability of the findings to females.
Participant Demographics
Male mice, including normal and GHRKO strains.
Statistical Information
P-Value
p<0.008
Confidence Interval
CI 1.31–6.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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