Clinical and Virological Factors Associated with Viremia in Pandemic Influenza A/H1N1/2009 Virus Infection
Author Information
Author(s): Tse Herman, Kelvin K. W. To, Wen Xi, Chen Honglin, Chan Kwok-Hung, Tsoi Hoi-Wah, Li Iris W. S., Yuen Kwok-Yung
Primary Institution: The University of Hong Kong
Hypothesis
The study aims to explore the clinical and virological factors associated with pandemic influenza A/H1N1/2009 viremia and to determine its clinical significance.
Conclusion
Presence of pandemic influenza A/H1N1/2009 viremia is an indicator of disease severity and strongly associated with D222G/N mutation in the viral hemagglutinin protein.
Supporting Evidence
- Viral RNA was detected in the blood of 14 patients.
- Viremia was strongly associated with severe clinical presentation.
- D222G/N quasispecies were observed in 90% of the blood samples.
Takeaway
This study found that when people get very sick from the flu, the virus can sometimes be found in their blood, which can mean they are more seriously ill.
Methodology
Clinical data of patients admitted to hospitals in Hong Kong between May 2009 and April 2010 were collected, and viral RNA was detected using RT-PCR from various specimens.
Limitations
The study's small sample size may limit the generalizability of the findings.
Participant Demographics
Patients included were adults admitted to hospitals in Hong Kong, with a mix of severe and mild cases.
Statistical Information
P-Value
p=0.0025
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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