High-dose folinic acid with 5-fluorouracil for advanced gastric and oesophageal cancer
Author Information
Author(s): M.S. Highley, M.E. Hill, N. Ziras, N. Samandas, R.C. Mason, W. Owen, J. Dussek, S. Barker, P.G. Harper
Primary Institution: Guy's Hospital
Hypothesis
Can high-dose folinic acid enhance the effectiveness of 5-fluorouracil in treating advanced gastric and oesophageal adenocarcinoma?
Conclusion
The treatment did not yield any objective responses, and results were disappointing compared to previous studies.
Supporting Evidence
- Seven patients (47%) had stable disease after treatment.
- The median interval to disease progression was 16 weeks.
- The median survival was 23 weeks.
- Twelve patients reported symptomatic improvement.
- Treatment was associated with mild toxicity reactions.
Takeaway
Doctors tried a new way to give medicine to help people with stomach cancer, but it didn't work as well as they hoped.
Methodology
15 patients were treated with a specific regimen of folinic acid and 5-FU, and their disease was assessed after six cycles.
Limitations
No objective responses were seen, and the results were less favorable than previous studies.
Participant Demographics
Median age was 62 years, with a range of 52-78 years; none had prior chemotherapy or radiotherapy.
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