Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis
2012
Prohibitin's Role in Abrin-Induced Cell Death
Sample size: 5
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Yu-Huei Liu, Peck Konan, Lin Jung-Yaw
Primary Institution: National Taiwan University
Hypothesis
Does prohibitin play a role in abrin-triggered apoptosis in Jurkat T cells?
Conclusion
Prohibitin is involved in abrin-induced apoptosis by enhancing the expression of pro-apoptotic genes.
Supporting Evidence
- ABR significantly induced the expression of Bax and activated caspase-3 in Jurkat T cells.
- Downregulation of prohibitin delayed abrin-triggered apoptosis.
- PHB was significantly upregulated in response to ABR treatment.
Takeaway
This study shows that a protein called prohibitin helps cancer cells die when exposed to a toxin from a plant called abrin.
Methodology
The study used Jurkat T cells treated with abrin to analyze gene expression changes and apoptosis through various assays.
Participant Demographics
Human Jurkat T leukemia cells were used in the study.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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