A new measure of population structure using multiple single nucleotide polymorphisms and its relationship with FST
2009
A New Measure of Population Structure Using SNPs
Sample size: 100
publication
Evidence: high
Author Information
Author(s): Xu Hongyan, Sarkar Bayazid, George Varghese
Primary Institution: Medical College of Georgia
Hypothesis
Can a new measure of population structure improve the understanding of genetic association studies?
Conclusion
The new measure provides an easy-to-interpret statistic for assessing population structure and differentiation.
Supporting Evidence
- The new measure C has high correlations with the traditional FST statistic.
- Correlation between FST and C increases with larger sample sizes and more SNPs.
- The new measure accounts for ascertainment bias in SNP discovery.
Takeaway
The researchers created a new way to measure how different groups of people are genetically, which helps in understanding diseases better.
Methodology
The study involved extensive simulations of samples with varying levels of population structure to compare the new measure with traditional FST.
Digital Object Identifier (DOI)
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