EVIDENCE SUPPORTING CERAMIDE ACCUMULATION AS A NOVEL HALLMARK OF AGING
2024
Ceramide Accumulation and Aging
publication
Evidence: moderate
Author Information
Author(s): Scroggins Laila, Echevarria Klarisse, Gutierrez Eduardo, Palavicini Juan, Quiles Penelope
Primary Institution: Howard University
Hypothesis
Ceramide accumulation is a major driver of aging.
Conclusion
Ceramide accumulation is linked to various age-related health issues and may be targeted for interventions to improve healthspan.
Supporting Evidence
- Ceramides accumulate with age in circulation and organs.
- Long-lived mice have reduced circulating ceramides.
- Rapamycin treatment reduces hepatic ceramides in old marmosets.
- Myriocin improves healthspan in various mouse strains.
Takeaway
As we get older, a type of fat called ceramide builds up in our bodies, which can make us sick, but there are ways to reduce it and help us live healthier.
Methodology
The study used various animal models to investigate ceramide levels and their effects on aging.
Digital Object Identifier (DOI)
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