Automation of a Liquid Chromatograph
Author Information
Author(s): A.D. Mills, I. Mackenzie, R.J. Dolphin
Primary Institution: Philips Research Laboratories
Hypothesis
The automation of a liquid chromatograph using a microcomputer can enhance its performance and flexibility.
Conclusion
The automated liquid chromatograph is reliable and flexible for both routine and research applications, achieving high precision and effective contamination control.
Supporting Evidence
- The automated system achieved a relative standard deviation of less than 1.1% for peak areas.
- Effective rinse and purge routines were developed to minimize carry-over contamination.
- The system allows for a high degree of user interaction and flexibility in operational modes.
Takeaway
This study shows how a computer can help a machine that tests liquids work better and faster, making it easier for scientists to get accurate results.
Methodology
The study involved the design and implementation of a microcomputer-controlled liquid chromatograph, including hardware and software development for data handling and sample analysis.
Limitations
The initial results were unsatisfactory until software modifications were made to improve performance.
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