TBP-1 and Akt in Cell Proliferation Control
Author Information
Author(s): Sepe Maria, Festa Luisa, Tolino Fabio, Bellucci Luca, Sisto Luca, Alfano Daniela, Ragno Pia, Calabrò Viola, de Franciscis Vittorio, La Mantia Girolama, Pollice Alessandra
Primary Institution: Dipartimento di Biologia Strutturale e Funzionale, Università di Napoli “Federico II”
Hypothesis
What are the molecular pathways involved in TBP-1's role in cell proliferation?
Conclusion
TBP-1 levels modulate Akt/PKB activation, affecting cell proliferation and apoptosis resistance.
Supporting Evidence
- TBP-1 silencing increases cell proliferation and migration.
- Reduced TBP-1 levels lead to higher Akt activation.
- TBP-1 depletion enhances resistance to apoptosis during serum deprivation.
Takeaway
When a protein called TBP-1 is reduced, cells grow faster and are better at surviving without food, which is important for understanding cancer.
Methodology
Stable knock-down of TBP-1 in human immortalized fibroblasts was used to study its effects on cell proliferation and Akt activation.
Participant Demographics
Human immortalized fibroblasts
Statistical Information
P-Value
p=0.046
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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