Foamy Virus Biology and Its Application for Vector Development
2011
Foamy Virus Biology and Its Application for Vector Development
publication
Evidence: moderate
Author Information
Author(s): Lindemann Dirk, Rethwilm Axel
Primary Institution: Technische Universität Dresden
Hypothesis
Foamy viruses have unique properties that may make them suitable for gene therapy applications.
Conclusion
Foamy viruses exhibit a distinct replication strategy and integration profile that could enhance their use as gene transfer vectors.
Supporting Evidence
- Foamy viruses are endemic in many non-human primates and can infect humans through zoonosis.
- They have a unique replication strategy that combines features of retroviruses and hepadnaviruses.
- Foamy viruses have shown potential for efficient gene transfer in various cell types.
Takeaway
Foamy viruses are special types of viruses that can help deliver genes into cells without causing disease, making them useful for treatments.
Methodology
This review summarizes the biology of foamy viruses and their potential as gene transfer systems.
Limitations
The review does not provide experimental data or specific studies to support the claims made.
Digital Object Identifier (DOI)
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