How Francisella tularensis Spreads in the Body
Author Information
Author(s): Sandra S. Ojeda, Zheng J. Wang, Chris A. Mares, Tingtung A. Chang, Qun Li, Elizabeth G. Morris, Paul A. Jerabek, Judy M. Teale
Primary Institution: University of Texas Health Science Center at San Antonio
Hypothesis
How does the route of infection affect the dissemination of Francisella tularensis in vivo?
Conclusion
The study found that the route of infection significantly influences the tissue tropism of Francisella tularensis, with a rapid preference for the lungs when inhaled.
Supporting Evidence
- Inhalation of F. tularensis led to rapid colonization of the lungs.
- MicroPET imaging showed significant tropism to the lung compared to other tissues.
- The cecum was identified as a novel site of colonization.
Takeaway
When mice get infected with a germ called Francisella tularensis, how they get infected changes where the germ goes in their body. If they breathe it in, it quickly goes to their lungs.
Methodology
Mice were infected with radiolabeled Francisella tularensis and imaged using microPET at various time points to track the bacteria's spread.
Limitations
The study primarily used a mouse model, which may not fully replicate human infection dynamics.
Participant Demographics
C57BL/6 female mice, aged 6-8 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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