IL-1ra Promotes Liver Regeneration
Author Information
Author(s): Sgroi Antonino, Gonelle-Gispert Carmen, Morel Philippe, Baertschiger Reto Marc, Niclauss Nadja, Mentha Gilles, Majno Pietro, Serre-Beinier Veronique, Buhler Leo
Primary Institution: Geneva University Hospital and University of Geneva
Hypothesis
The study aims to evaluate the role of interleukin-1 receptor antagonist (IL-1ra) during liver regeneration and the effect of a recombinant human IL-1ra on liver regeneration.
Conclusion
IL-1ra modulates the early phase of liver regeneration by decreasing inflammatory stress and accelerating hepatocyte proliferation.
Supporting Evidence
- IL-1ra KO mice had significantly higher levels of pro-inflammatory cytokines and reduced hepatocyte proliferation compared to WT mice.
- WT mice treated with anakinra showed significantly decreased levels of IL-6 and higher hepatocyte proliferation at 24h compared to untreated WT mice.
- In vitro, primary human hepatocytes treated with anakinra showed significantly higher proliferation at 24h compared to untreated hepatocytes.
Takeaway
This study shows that a protein called IL-1ra helps the liver heal faster after surgery by reducing inflammation and helping liver cells grow.
Methodology
The study involved performing 70%-hepatectomy in wild type and IL-1ra knock-out mice, followed by analysis of liver regeneration through various biochemical and histological methods.
Limitations
The study was conducted in mice, which may not fully replicate human liver regeneration processes.
Participant Demographics
10 to 12 week-old male DBA1 mice were used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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