Immunopathology and Immunogenetics of Allergic Bronchopulmonary Aspergillosis
2011
Understanding Allergic Bronchopulmonary Aspergillosis
publication
Evidence: moderate
Author Information
Author(s): Alan P. Knutsen
Primary Institution: Saint Louis University
Hypothesis
ABPA develops in genetically susceptible individuals with asthma and CF due to increased frequency and/or activity of A. fumigatus-specific Th2 CD4+ cells.
Conclusion
Early diagnosis and treatment of ABPA are crucial to prevent permanent lung damage.
Supporting Evidence
- ABPA affects approximately 1%–2% of asthmatic patients and 7%–9% of CF patients.
- Genetic risks for ABPA include specific HLA and IL-4 receptor polymorphisms.
- Elevated serum IgE levels are characteristic of ABPA.
Takeaway
Some people with asthma or cystic fibrosis can get a lung disease called ABPA from a mold. If doctors find it early, they can help people feel better and keep their lungs safe.
Limitations
The diagnosis of ABPA can be complicated due to overlapping symptoms with cystic fibrosis.
Participant Demographics
ABPA primarily affects asthmatic and cystic fibrosis patients.
Digital Object Identifier (DOI)
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