Sfrp Controls Cell Polarity in the Developing Gut
Author Information
Author(s): Matsuyama Makoto, Aizawa Shinichi, Shimono Akihiko
Primary Institution: Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Japan
Hypothesis
Sfrp regulation of Wnt5a signaling is required for oriented cell division and apicobasal polarity in gut epithelium during organ elongation.
Conclusion
Inactivation of Sfrp1 and Sfrp2 leads to reduced fore-stomach length in mouse embryos and disrupts oriented cell division.
Supporting Evidence
- Inactivation of Sfrp1 and Sfrp2 leads to a significant reduction in fore-stomach length.
- Cell division orientation diverges in Sfrps-deficient fore-stomach epithelium.
- Sfrp1 physically interacts with Wnt5a and inhibits Wnt5a signaling.
- Oriented cell division is essential for fore-stomach morphogenesis.
Takeaway
Sfrp proteins help cells in the gut divide in the right direction, which is important for the gut to grow properly.
Methodology
The study involved genetic analysis of Sfrp1, Sfrp2, and Sfrp5 in mouse embryos to observe their effects on gut morphogenesis.
Limitations
The study primarily focuses on specific Sfrp genes and may not account for other factors influencing gut development.
Participant Demographics
Mouse embryos were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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