Polymorphisms in miRNA Binding Sites and Osteoporosis
Author Information
Author(s): Lei Shu-Feng, Papasian Christopher J, Deng Hong-Wen
Primary Institution: Hunan Normal University
Hypothesis
The study investigates the association between polymorphisms in predicted miRNA binding sites and osteoporosis risk.
Conclusion
Three polymorphisms in the FGF2 gene are significantly associated with femoral neck bone mineral density, suggesting they may contribute to osteoporosis susceptibility.
Supporting Evidence
- Three polymorphisms in the FGF2 gene were identified as significantly associated with femoral neck BMD.
- Gene expression analyses showed differential expression of the FGF2 gene in subjects with high versus low BMD.
- Initial and replication studies consistently supported the association of these polymorphisms with osteoporosis risk.
Takeaway
The study found that certain genetic variations can affect bone density, which might make some people more likely to develop osteoporosis.
Methodology
Association analyses were performed on 568 polymorphisms in 3'-UTRs of target mRNAs in a sample of 997 white subjects, followed by replication in 1728 subjects.
Potential Biases
Potential confounding effects from population structure were minimized but not completely eliminated.
Limitations
The study primarily focused on white subjects, which may limit the generalizability of the findings to other populations.
Participant Demographics
997 unrelated white subjects aged approximately 50 years in the initial study and 1728 unrelated white women in the replication study.
Statistical Information
P-Value
p = 4.18E-03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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