Genetic Factors Affecting Malaria Susceptibility
Author Information
Author(s): Driss Adel, Hibbert Jacqueline M, Wilson Nana O, Iqbal Shareen A, Adamkiewicz Thomas V, Stiles Jonathan K
Primary Institution: Morehouse School of Medicine
Hypothesis
What genetic polymorphisms are associated with susceptibility or resistance to Plasmodium falciparum malaria?
Conclusion
Genetic polymorphisms play a significant role in determining susceptibility to malaria, but many findings are inconclusive and require further investigation.
Supporting Evidence
- Genetic polymorphisms have been linked to malaria resistance and susceptibility.
- Different genes affect various malaria-related phenotypes.
- Recent advances in genetic research have identified new polymorphisms associated with malaria.
Takeaway
Some people are more likely to get malaria because of their genes, and scientists are trying to figure out which genes help protect against it.
Methodology
The review discusses findings from genome-wide association studies (GWAS) and other genetic studies related to malaria susceptibility.
Potential Biases
Population stratification and environmental factors may influence the results.
Limitations
Many genetic associations are inconclusive and may vary across different populations.
Participant Demographics
The study includes children from The Gambia and other populations in Africa, Europe, and Asia.
Digital Object Identifier (DOI)
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