Role of Protein 4.1B in Myelinated Axons
Author Information
Author(s): Carmen Cifuentes-Diaz, Fabrice Chareyre, Marta Garcia, Jérôme Devaux, Michèle Carnaud, Grégoire Levasseur, Michiko Niwa-Kawakita, Sheila Harroch, Jean-Antoine Girault, Marco Giovannini, Laure Goutebroze
Primary Institution: Inserm, UMR-S 839, Paris, France
Hypothesis
What is the role of protein 4.1B in the organization of myelinated peripheral axons?
Conclusion
Protein 4.1B is crucial for the stabilization of membrane proteins at paranodes and the clustering of juxtaparanodal proteins in myelinated axons.
Supporting Evidence
- 4.1B knockout mice displayed a mildly impaired gait and motility.
- The distribution of Caspr/paranodin was disorganized in paranodal regions of knockout mice.
- Electrophysiological recordings indicated neuronal hyperexcitability in 4.1B knockout mice.
- Ultrastructural abnormalities were observed in the axons of knockout mice.
- Protein 4.1B is essential for the localization of Caspr2 and TAG-1 at juxtaparanodes.
Takeaway
Protein 4.1B helps keep the parts of nerve cells that send signals organized, which is important for them to work properly.
Methodology
The study involved generating 4.1B knockout mice and analyzing their behavior, protein localization, and electrophysiological properties.
Limitations
The study primarily focused on the effects in mice, which may not fully translate to human conditions.
Participant Demographics
Mice used in the study included wild type and 4.1B knockout variants.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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