Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus
2010
Role of Lipids on Entry and Exit of Bluetongue Virus
publication
Evidence: moderate
Author Information
Author(s): Bhattacharya Bishnupriya, Roy Polly
Primary Institution: London School of Hygiene & Tropical Medicine
Hypothesis
Bluetongue virus interacts with lipids during its entry and exit processes.
Conclusion
The study reveals that Bluetongue virus utilizes a clathrin-mediated pathway for entry into host cells and interacts with lipid rafts during its replication.
Supporting Evidence
- Bluetongue virus enters host cells via a clathrin-mediated endocytic pathway.
- VP2 and VP5 proteins of Bluetongue virus interact with lipid rafts during replication.
- Depletion of cholesterol affects the association of VP5 with lipid rafts and decreases viral titer.
Takeaway
Bluetongue virus needs lipids to get into and out of cells, kind of like how a key fits into a lock.
Methodology
The study involved biochemical and structural analyses, including confocal microscopy and cryo-electron microscopy.
Digital Object Identifier (DOI)
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