Do Proton Pump Inhibitors Decrease Calcium Absorption?
Author Information
Author(s): Hansen Karen E, Jones Andrea N, Lindstrom Mary J, Davis Lisa A, Ziegler Toni E, Penniston Kristina L, Alvig Amy L, Shafer Martin M
Primary Institution: University of Wisconsin
Hypothesis
Does PPI therapy affect fractional calcium absorption in postmenopausal women?
Conclusion
Thirty days of continuous PPI therapy did not alter fractional calcium absorption in postmenopausal women.
Supporting Evidence
- Participants underwent three 24-hour inpatient calcium absorption studies.
- FCA was measured using the dual stable isotope method, considered the gold standard.
- Subjects' PTH, serum calcium, and urine calcium levels remained stable throughout the study.
Takeaway
This study looked at whether a common medication affects how well older women absorb calcium. It found that the medication didn't change calcium absorption after a month.
Methodology
The study used a dual stable isotope method to measure fractional calcium absorption in postmenopausal women before and after 30 days of omeprazole therapy.
Potential Biases
Participants were relatively young and healthy, which may not represent the broader population of PPI users.
Limitations
The study's short duration may not capture long-term effects of PPI therapy on calcium absorption.
Participant Demographics
Participants were 21 postmenopausal women, mean age 58 years, with 17 white, 2 black, and 2 Hispanic.
Statistical Information
P-Value
p = .07
Confidence Interval
95% CI 1.10–1.20
Statistical Significance
p = .07
Digital Object Identifier (DOI)
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