Do Proton Pump Inhibitors Decrease Calcium Absorption?
2010

Do Proton Pump Inhibitors Decrease Calcium Absorption?

Sample size: 21 publication 10 minutes Evidence: moderate

Author Information

Author(s): Hansen Karen E, Jones Andrea N, Lindstrom Mary J, Davis Lisa A, Ziegler Toni E, Penniston Kristina L, Alvig Amy L, Shafer Martin M

Primary Institution: University of Wisconsin

Hypothesis

Does PPI therapy affect fractional calcium absorption in postmenopausal women?

Conclusion

Thirty days of continuous PPI therapy did not alter fractional calcium absorption in postmenopausal women.

Supporting Evidence

  • Participants underwent three 24-hour inpatient calcium absorption studies.
  • FCA was measured using the dual stable isotope method, considered the gold standard.
  • Subjects' PTH, serum calcium, and urine calcium levels remained stable throughout the study.

Takeaway

This study looked at whether a common medication affects how well older women absorb calcium. It found that the medication didn't change calcium absorption after a month.

Methodology

The study used a dual stable isotope method to measure fractional calcium absorption in postmenopausal women before and after 30 days of omeprazole therapy.

Potential Biases

Participants were relatively young and healthy, which may not represent the broader population of PPI users.

Limitations

The study's short duration may not capture long-term effects of PPI therapy on calcium absorption.

Participant Demographics

Participants were 21 postmenopausal women, mean age 58 years, with 17 white, 2 black, and 2 Hispanic.

Statistical Information

P-Value

p = .07

Confidence Interval

95% CI 1.10–1.20

Statistical Significance

p = .07

Digital Object Identifier (DOI)

10.1002/jbmr.166

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