Improving Heart Function Assessment in Mice with Fewer Images
Author Information
Author(s): Young Alistair A, Medway Debra J, Lygate Craig A, Neubauer Stefan, Schneider Jürgen E
Primary Institution: Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
Hypothesis
3D guide-point modeling can achieve results of similar accuracy to the standard analysis in mice with myocardial infarction using fewer slices.
Conclusion
GPM allows accurate analysis of left ventricular function in mice using a reduced number of image slices.
Supporting Evidence
- GPM enables accurate analysis of LV function in mice with large infarcts.
- No significant differences were found in LV mass and volumes between standard and GPM protocols in control mice.
- A significant difference was found in LV mass using the GPM four slice protocol in infarcted mice.
Takeaway
Scientists found a way to check mouse hearts using fewer pictures, which makes it quicker and easier to see how well the heart is working.
Methodology
CMR examination of mice with myocardial infarction and control mice using different slice acquisition protocols.
Potential Biases
Operator bias may be introduced in contour placement.
Limitations
Inter-study and inter-observer reproducibility were not directly evaluated.
Participant Demographics
Five female and six male C57Bl/6 mice.
Statistical Information
P-Value
0.045
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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