Effects of Brazilian Propolis on Human Leukemic Cells
Author Information
Author(s): Gilberto C. Franchi Jr., Cleber S. Moraes, Viviane C. Toreti, Andreas Daugsch, Alexandre E. Nowill, Yong K. Park
Primary Institution: State University of Campinas
Hypothesis
The study aims to compare the cytotoxic activities of green propolis and red propolis in human leukemia cells.
Conclusion
Red propolis is more cytotoxic than green propolis in various human leukemia cell lines.
Supporting Evidence
- Red propolis showed higher cytotoxicity than green propolis in all tested leukemia cell lines.
- The IC50 values for red propolis were significantly lower than those for green propolis.
- Red propolis caused similar apoptosis levels as the control drug Gleevec in K562 cells.
Takeaway
This study found that red propolis can kill more leukemia cells than green propolis, which might help in cancer treatment.
Methodology
The study used MTT assays to assess the cytotoxicity of ethanolic extracts of green and red propolis on various human leukemia cell lines.
Limitations
The study was based on in vitro experiments, which may not fully represent in vivo effects.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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