Oxidative Stress and Antioxidant Status in Sarcoma Patients
Author Information
Author(s): Nathan Fatima M, Singh Vivek A, Dhanoa Amreeta, Palanisamy Uma D
Primary Institution: Monash University
Hypothesis
This study aims to determine the levels of oxidative stress and antioxidant defence in patients with primary bone and soft tissue sarcoma.
Conclusion
The study found increased oxidative stress and decreased antioxidant status in both primary bone and soft tissue sarcomas.
Supporting Evidence
- Sarcoma patients showed significant increases in plasma and urinary MDA and serum protein carbonyl levels.
- Significant decreases were noted in TEAC, thiols, CAT, and SOD levels in sarcoma patients.
- No significant difference in oxidative damage was noted between bone and soft tissue sarcomas.
Takeaway
Patients with certain types of cancer have more damage from harmful substances in their bodies and less ability to fight it off.
Methodology
The study involved 94 subjects, including sarcoma patients and healthy controls, measuring oxidative stress and antioxidant levels through various biochemical assays.
Limitations
The study's findings may not be generalizable due to the specific cohort size and characteristics.
Participant Demographics
The study included 47 patients with bone and soft tissue sarcoma, aged 7 to 78 years, with 28 males and 19 females.
Statistical Information
P-Value
0.000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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