Bladder Sensory Desensitization and Urinary Urgency
Author Information
Author(s): Silva Carlos, Silva João, Castro Helder, Reis Frederico, Dinis Paulo, Avelino António, Cruz Francisco
Primary Institution: Hospital S. João and Faculty of Medicine of Porto, Porto, Portugal
Hypothesis
Can bladder desensitization reduce urinary urgency in patients with overactive bladder?
Conclusion
Bladder desensitization may be a useful alternative treatment for patients with urinary urgency, especially those who do not respond to standard management.
Supporting Evidence
- The mean number of urgency episodes decreased from 71 to 39 after treatment with RTX.
- 69% of patients reported subjective improvement after RTX treatment.
- Only 17% of patients felt improved enough to repeat the vehicle treatment.
Takeaway
This study found that a special treatment can help people who really need to go to the bathroom a lot feel better and go less often.
Methodology
Patients underwent a 30-day run-in period without bladder-affecting medications, followed by instillations of a vehicle solution and then resiniferatoxin, with voiding charts collected at various intervals.
Potential Biases
Potential bias due to the lack of a control group receiving a placebo treatment.
Limitations
The study was exploratory and not designed as a randomized controlled trial, which may limit the generalizability of the findings.
Participant Demographics
23 patients (7 males and 16 females) with a mean age of 50 years, range 21–77; 6 had a neurogenic cause for OAB symptoms.
Statistical Information
P-Value
0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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