How Herpes Simplex Virus Evades the Immune System
Author Information
Author(s): Jesper Melchjorsen, Sampsa Matikainen, Søren R. Paludan
Primary Institution: Aarhus University Hospital
Hypothesis
Understanding the mechanisms by which herpes simplex virus (HSV) evades the innate immune response can improve our knowledge of viral pathogenesis.
Conclusion
Herpes simplex virus employs multiple strategies to evade the innate immune response, particularly through the inhibition of interferon signaling.
Supporting Evidence
- HSV has evolved strategies to evade the production and function of interferons and cytokines.
- Type I interferons are crucial for antiviral response against HSV.
- HSV can inhibit the activation of immune signaling pathways to enhance its replication.
Takeaway
Herpes simplex virus is like a sneaky thief that hides from the body's defenses, making it hard for the body to fight it off.
Methodology
This review summarizes current knowledge on the induction and evasion of the innate immune response by HSV.
Limitations
The review primarily focuses on existing literature and may not cover all recent findings.
Digital Object Identifier (DOI)
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