EP3 Expression in Human Conjunctival Epithelium and Ocular Surface Disorders
Author Information
Author(s): Ueta Mayumi, Sotozono Chie, Yokoi Norihiko, Inatomi Tsutomu, Kinoshita Shigeru
Primary Institution: Kyoto Prefectural University of Medicine
Hypothesis
The study investigates the expression of EP3 protein in the conjunctiva of patients with various ocular surface diseases.
Conclusion
EP3 is down-regulated in the conjunctival epithelium of patients with Stevens-Johnson syndrome and ocular cicatricial pemphigoid.
Supporting Evidence
- EP3 was expressed in the conjunctival epithelium of patients with chemical eye burns and Mooren’s ulcer.
- EP3 expression was markedly down-regulated in the conjunctival epithelium of SJS/TEN and OCP patients.
- Normal conjunctival epithelium showed high levels of EP3 expression.
Takeaway
This study looks at a protein called EP3 in the eyes of people with certain eye diseases, finding that it is less present in some patients, which might help doctors understand these diseases better.
Methodology
Conjunctival tissues were obtained from patients undergoing surgical reconstruction and analyzed using immunohistological methods.
Limitations
The study had a small sample size for some conditions and included only a limited number of patients with certain diseases.
Participant Demographics
Patients included those with Stevens-Johnson syndrome, chemical eye burns, Mooren’s ulcers, and ocular cicatricial pemphigoid.
Digital Object Identifier (DOI)
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