Feasibility of Early Infant Diagnosis of HIV in Resource-Limited Settings: The ANRS 12140-PEDIACAM Study in Cameroon
2011

Early Infant Diagnosis of HIV in Cameroon

Sample size: 1587 publication 10 minutes Evidence: moderate

Author Information

Author(s): Tejiokem Mathurin C., Faye Albert, Penda Ida C., Guemkam Georgette, Ateba Ndongo Francis, Chewa Gisèle, Rekacewicz Claire, Rousset Dominique, Kfutwah Anfumbom, Boisier Pascal, Warszawski Josiane

Primary Institution: Centre Pasteur du Cameroun

Hypothesis

The study evaluates the feasibility and effectiveness of early infant diagnosis (EID) of HIV in urban areas of Cameroon.

Conclusion

The study found that a high percentage of HIV-infected women diagnosed early during pregnancy opted for early infant diagnosis, but improvements are needed to reduce incomplete diagnosis processes.

Supporting Evidence

  • 89.7% of infants were tested for HIV at a median age of 1.5 months.
  • 83.9% of infants completed the EID process before 7 months.
  • Late HIV diagnosis during pregnancy was associated with incomplete EID.

Takeaway

This study shows that many mothers in Cameroon are getting their babies tested for HIV early, but some still miss out on important follow-up care.

Methodology

The study was a multisite cohort where infants born to HIV-infected mothers were included and followed for HIV testing and treatment.

Potential Biases

Potential bias due to loss to follow-up and incomplete data on maternal health and socio-economic status.

Limitations

The study did not include all infants born to HIV-infected mothers, and some infants' vital status could not be determined.

Participant Demographics

Infants born to HIV-infected mothers, median maternal age 29.2 years, 51.8% male infants.

Statistical Information

P-Value

0.01

Confidence Interval

95%CI: 1.1 to 2.9

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0021840

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