Changes in Antimicrobial Resistance in Salmonella enterica Serovar Typhimurium
2000
Emergence of Multidrug-Resistant Salmonella Typhimurium
publication
Evidence: moderate
Author Information
Author(s): Frederick J. Angulo, Patricia M. Griffin
Primary Institution: Centers for Disease Control and Prevention
Hypothesis
The use of antimicrobial agents in aquaculture in Asia may have contributed to the emergence of multidrug-resistant Salmonella serotype Typhimurium DT104.
Conclusion
The emergence and spread of MR-DT104 suggest that its resistance determinants may have originated in aquaculture and been transferred to Salmonella Typhimurium.
Supporting Evidence
- The resistant determinants of MR-DT104 reside on the chromosome within a transferrable element.
- Chloramphenicol resistance in MR-DT104 is due to the floR gene, which is a florfenicol resistance gene.
- Tetracycline resistance in MR-DT104 is due to a class G resistance gene first identified in Vibrio anguillarum.
- The molecular sequence of resistance determinants in DT104 is closely related to a plasmid in Pasteurella piscicida.
- Once MR-DT104 is introduced into food animals, the use of antimicrobial agents would contribute to its further spread.
Takeaway
Some bacteria can become resistant to medicines, and this study thinks that fish farms in Asia might be part of the problem for a specific type of Salmonella that is hard to treat.
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