Increased Tissue Factor and RAGE in Type 2 Diabetes Patients with Vascular Complications
Author Information
Author(s): A. E. Buchs, A. Kornberg, M. Zahavi, D. Aharoni, C. Zarfati, M. J. Rapoport
Primary Institution: Assaf Harofeh Medical Center, Zerifin, Israel
Hypothesis
The study aims to determine the correlation between the expression of tissue factor (TF) and the receptor for advanced glycation end products (RAGEs) and vascular complications in patients with longstanding uncontrolled type 2 diabetes.
Conclusion
The study found that tissue factor and RAGE expression are significantly increased in patients with type 2 diabetes who have vascular complications compared to those without.
Supporting Evidence
- TF mRNA expression was significantly higher in patients with complications compared to those without.
- Basal TF activity was significantly higher in patients with complications.
- RAGE mRNA expression was also increased in patients with complications.
Takeaway
This study shows that patients with type 2 diabetes and blood vessel problems have higher levels of certain proteins that might be making their condition worse.
Methodology
The study assessed TF and RAGE mRNA expression and activity in peripheral blood mononuclear cells from 21 patients with type 2 diabetes, using RT-PCR and ELISA.
Potential Biases
Potential bias due to the exclusion criteria and the small sample size.
Limitations
The study did not separate male and female patients and could not exclude minor asymptomatic macrovascular disease in noncomplicated patients.
Participant Demographics
21 patients (13 males and 8 females, age range 41 to 82 years) with longstanding uncontrolled type 2 diabetes.
Statistical Information
P-Value
P = .003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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