Role of Carbon Monoxide in Allergic Rhinitis in Guinea Pigs
Author Information
Author(s): Shaoqing Yu, Ruxin Zhang, Yinjian Chen, Jianqiu Chen, Chunsheng Zhu, Jiangfeng Tang, Genhong Li
Primary Institution: Department of Otolaryngology, Jinan General Hospital of PLA, Shandong, PR China
Hypothesis
The study investigates the possible roles of carbon monoxide in the pathogenesis of allergic rhinitis.
Conclusion
Endogenous carbon monoxide may contribute to the inflammation process of allergic rhinitis and is positively correlated with the expression of heme oxygenase-1 in the nasal mucosa.
Supporting Evidence
- The frequency of sneezing and nose rubbing was higher in sensitized guinea pigs compared to controls.
- Leukocyte infiltration and serum IgE levels were significantly increased in the AR group.
- Hemin treatment increased CO levels and symptoms, while ZnPP treatment decreased them.
Takeaway
The study found that carbon monoxide might make allergies worse in guinea pigs, and it works together with a protein called HO-1.
Methodology
Guinea pigs were sensitized with ovalbumin and divided into groups for treatment with saline, Hemin, or ZnPP, with measurements of sneezing, nose rubbing, leukocyte infiltration, serum IgE, and plasma CO.
Participant Demographics
Twenty-four adult healthy male Hartley guinea pigs (230–280 g).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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