Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration
Author Information
Author(s): Saska S., Barud H. S., Gaspar A. M. M., Marchetto R., Ribeiro S. J. L., Messaddeq Y.
Primary Institution: Institute of Chemistry, University Estadual Paulista—UNESP
Hypothesis
The study aims to develop and evaluate the biological properties of bacterial cellulose-hydroxyapatite (BC-HA) nanocomposite membranes for bone regeneration.
Conclusion
BC-HA membranes were effective for bone regeneration in bone defects of rat tibiae, accelerating new bone formation at the defect sites.
Supporting Evidence
- BC-HA membranes showed no inflammatory reaction after 1 week.
- Defects were completely filled in by new bone tissue after 4 weeks.
- Thermogravimetric analyses showed that the mineral phase was 40%-50% of the total weight.
- Histological analysis revealed that BC-HA membranes promoted effective bone formation.
- BC-HA composites have a Ca/P molar ratio similar to physiological bone.
Takeaway
Scientists created a special material from bacteria that helps bones heal better and faster when there's a break.
Methodology
Bacterial cellulose membranes were treated with calcium and phosphate solutions to create BC-HA composites, which were then tested in rat bone defects.
Limitations
The study was conducted on a small sample size of rats, which may limit the generalizability of the results.
Participant Demographics
Eighteen male adult rats (Rattus Norvevicus Holtzman) were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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