Lymph Vessel Density in Early-Stage Cervical Cancer
Author Information
Author(s): Zhang Shi-qian, Yu Hao, Zhang Lin-lin
Primary Institution: Department of Gynecology, Qilu Hospital, Shandong University
Hypothesis
The study investigates the clinical implications of lymphangiogenesis in the metastasis of early-stage invasive cervical carcinoma.
Conclusion
Lymphangiogenesis may play an important role in the lymphatic metastasis of early-stage invasive cervical carcinoma.
Supporting Evidence
- The peritumoral lymphatic vessel density was significantly higher than the intratumoral lymphatic vessel density.
- Both intratumoral and peritumoral lymphatic vessel densities were significantly associated with lymph node metastasis.
- Histological grade was correlated with lymph vessel density, with higher grades showing increased density.
Takeaway
This study found that more lymph vessels around cervical tumors might help cancer spread to other parts of the body.
Methodology
Immunohistochemical staining was used to measure lymph vessel density in cervical carcinoma and normal samples.
Participant Demographics
Patients aged 26 to 70, with a median age of 42; 29 premenopausal and 16 postmenopausal.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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