Effects of Mild Hypothermia on Platelet Aggregation After Clopidogrel Treatment
Author Information
Author(s): Carl Högberg, David Erlinge, Oscar Ö Braun
Primary Institution: Lund University
Hypothesis
Does mild hypothermia affect platelet aggregation during clopidogrel treatment?
Conclusion
Mild hypothermia did not reduce platelet aggregation; instead, it increased ADP-stimulated platelet aggregation after clopidogrel treatment.
Supporting Evidence
- Platelet aggregation was unaltered or increased by hypothermia.
- ADP-induced platelet aggregation increased significantly at lower temperatures after clopidogrel treatment.
- The effect of clopidogrel was reduced during mild hypothermia.
Takeaway
When people are cooled down a bit, their blood cells can stick together more easily after taking a medicine called clopidogrel.
Methodology
Platelet reactivity was evaluated using light transmission aggregometry and VASP in blood from healthy volunteers before and after clopidogrel treatment.
Limitations
The study was conducted on a small sample size of healthy volunteers, which may not represent all patient populations.
Participant Demographics
Healthy volunteers
Statistical Information
P-Value
p<0.001
Confidence Interval
0.41–0.93
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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