H-RAS T81C Polymorphism and Gastrointestinal Cancer Risk
Author Information
Author(s): Zhang Yongjing, Jin Mingjuan, Liu Bing, Ma Xinyuan, Yao Kaiyan, Li Qilong, Chen Kun
Primary Institution: Zhejiang University School of Medicine
Hypothesis
The H-RAS T81C polymorphism may influence susceptibility to gastrointestinal cancer.
Conclusion
The H-RAS T81C polymorphism is associated with an increased risk of gastric cancer in the Chinese population.
Supporting Evidence
- The TC genotype was significantly associated with an increased risk of gastric cancer.
- The CC genotype showed an increased risk but was not statistically significant.
- No significant association was found between H-RAS T81C polymorphism and colon or rectal cancer.
Takeaway
This study found that a specific gene change might make people more likely to get stomach cancer.
Methodology
A population-based case-control study with 296 cancer patients and 448 healthy controls was conducted, using PCR-RFLP for genotyping.
Limitations
The study had a relatively small sample size and lacked data on Helicobacter pylori infection.
Participant Demographics
Participants were ethnic Han Chinese residents, including 169 males and 127 females with gastrointestinal cancer.
Statistical Information
P-Value
<0.0001
Confidence Interval
95%CI = 2.22–6.00
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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