Long Non-Coding RNAs in Human Tissues and Cancers
Author Information
Author(s): Gibb Ewan A., Vucic Emily A., Enfield Katey S. S., Stewart Greg L., Lonergan Kim M., Kennett Jennifer Y., Becker-Santos Daiana D., MacAulay Calum E., Lam Stephen, Brown Carolyn J., Lam Wan L.
Primary Institution: British Columbia Cancer Agency Research Centre
Hypothesis
What are the transcription patterns of long non-coding RNAs (lncRNAs) across normal human tissues and cancers?
Conclusion
The study provides a comprehensive atlas of lncRNA expression profiles, revealing extensive tissue-specific expression in normal tissues and aberrant expression in various cancers.
Supporting Evidence
- The study analyzed 272 SAGE libraries representing 26 normal human tissues and 19 human cancers.
- It found extensive, tissue-specific lncRNA expression in normal tissues.
- Aberrant lncRNA expression patterns were identified in various human cancers.
- The research provides a first generation atlas for lncRNA profiling in cancer.
Takeaway
This study looked at special types of RNA that don't make proteins but are important for how our cells work, finding that they behave differently in healthy tissues compared to cancer.
Methodology
The study compiled 272 human SAGE libraries to analyze lncRNA transcription patterns using a custom lncRNA discovery pipeline.
Limitations
The study primarily focused on polyadenylated lncRNAs, potentially missing non-polyadenylated variants.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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