Arginine Metabolism Modulators and Cancer Immunity
Author Information
Author(s): Giusy Capuano, Nicolò Rigamonti, Matteo Grioni, Massimo Freschi, Matteo Bellone
Primary Institution: Istituto Scientifico San Raffaele
Hypothesis
Does the accumulation of myeloid derived suppressor cells (MDSC) in tumor-bearing mice affect antitumor immunity, and can modulators of arginine metabolism restore this immunity?
Conclusion
The study shows that modulators of arginine metabolism can enhance antitumor immunity and inhibit tumor growth in mice.
Supporting Evidence
- MDSC accumulate in the spleen and blood of tumor-bearing mice.
- Treatment with L-NAME or sildenafil significantly restrained tumor growth.
- Both treatments expanded the tumor-specific immune response.
Takeaway
Mice with tumors have special cells that stop their immune system from working. Some medicines can help the immune system fight the tumor better.
Methodology
The study involved treating tumor-bearing mice with L-NAME or sildenafil and measuring tumor growth and immune responses.
Potential Biases
Potential bias in the interpretation of results due to the use of specific mouse strains and tumor models.
Limitations
The study was conducted in mouse models, which may not fully replicate human responses.
Participant Demographics
BALB/c and C57BL/6 mice, 8-10 weeks old.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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