Sample Size Requirements for Genetic Variant Studies
Author Information
Author(s): Moonesinghe Ramal, Yang Quanhe, Khoury Muin J
Primary Institution: Centers for Disease Control and Prevention
Hypothesis
What is the sample size required to detect the effect of a group of genetic variants in case-control studies?
Conclusion
A smaller sample size is needed to detect the effect of a group of genetic variants compared to individual variants, making it a useful screening tool.
Supporting Evidence
- The sample size requirement declines with increasing numbers of genetic variants.
- For a group of 10 genetic variants, the sample size requirement can decline by approximately 79% compared to a single variant.
- The method can be used as a screening tool for assessing groups of genetic variants involved in disease.
Takeaway
To find out if a group of genes affects health, you don't need as many people in a study as you might think; testing groups of genes can be easier.
Methodology
A method for determining sample sizes required to detect the average joint effect of a group of genetic variants in case-control studies was presented.
Potential Biases
Potential biases include selection bias and confounding factors in study design.
Limitations
The method cannot assess higher order interactions and assumes independence between genetic variants.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website