Palinopsia Linked to Ribociclib in Breast Cancer Treatment
Author Information
Author(s): Martos Tamara, Saint-Gerons Marta, Masfarre Laura, Castro-Henriques Maria, Martinez-Garcia Maria, Servitja Sonia, Albanell Joan
Primary Institution: Hospital del Mar, Parc de Salut Mar, Barcelona, Spain
Hypothesis
Can ribociclib cause palinopsia in patients with metastatic breast cancer?
Conclusion
Ribociclib may be associated with palinopsia, a rare visual disturbance, in patients undergoing treatment for metastatic breast cancer.
Supporting Evidence
- Palinopsia was observed in both patients during ribociclib therapy.
- Neuro-ophthalmological assessments showed no organic cause for the visual disturbances.
- Symptoms of palinopsia were time- and dose-dependent with ribociclib intake.
Takeaway
Some patients taking ribociclib for breast cancer might see things that aren't there, but it usually goes away when they stop the medicine.
Methodology
Case reports of two patients experiencing palinopsia during ribociclib treatment, with neuro-ophthalmological assessments and brain MRIs conducted.
Potential Biases
Potential bias in reporting due to the small sample size and reliance on patient self-reports.
Limitations
The study is based on only two case reports, limiting generalizability.
Participant Demographics
Two female patients, one aged 46 and the other 28, both with HR-positive, HER2-negative metastatic breast cancer.
Digital Object Identifier (DOI)
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