Understanding the Metabolic Network of Buchnera aphidicola
Author Information
Author(s): Thomas Gavin H, Zucker Jeremy, Macdonald Sandy J, Sorokin Anatoly, Goryanin Igor, Douglas Angela E
Primary Institution: Department of Biology, University of York
Hypothesis
How is the metabolic network of the symbiotic bacterium Buchnera aphidicola controlled by its host?
Conclusion
The study predicts that the fragility of the bacterial metabolic network makes Buchnera aphidicola intolerant to drastic environmental changes, while its histidine production is tightly linked to its growth and host nutrient supply.
Supporting Evidence
- Buchnera aphidicola has a fragile metabolic network with over 90% of reactions essential for viability.
- The bacterium cannot grow without producing histidine, which is provided to the insect host.
- The metabolic network is poorly connected compared to E. coli, indicating limited redundancy.
Takeaway
Buchnera aphidicola is a tiny bacterium that helps aphids by providing them with essential nutrients, but it is very sensitive to changes in its environment.
Methodology
The study used in silico analysis and flux balance analysis to reconstruct and analyze the metabolic network of Buchnera aphidicola.
Limitations
The model may not fully capture the complexity of in vivo conditions due to its reliance on in silico methods.
Digital Object Identifier (DOI)
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