Radiation Exposure from 11C-CUMI-101 in Brain Imaging
Author Information
Author(s): Hines Christina S., Liow Jeih-San, Zanotti-Fregonara Paolo, Hirvonen Jussi, Morse Cheryl, Pike Victor W., Innis Robert B.
Primary Institution: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, United States of America
Hypothesis
The study aims to calculate the radiation exposure to organs of the body based on whole-body imaging with 11C-CUMI-101 in healthy volunteers.
Conclusion
The effective dose of 11C-CUMI-101 is 5.3±0.5 microSv/MBq, which is comparable to other 11C-labeled ligands for brain imaging.
Supporting Evidence
- The effective dose of 11C-CUMI-101 was found to be 5.3±0.5 microSv/MBq.
- Peak brain uptake of 11C-CUMI-101 was about 11% IA at 10 minutes post-injection.
- The liver had the highest uptake of radioactivity, reaching about 35% IA by the end of the scan.
- Three of the nine subjects had transiently elevated plasma CK after injection, but these were asymptomatic.
Takeaway
This study looked at how much radiation people get from a brain imaging drug called 11C-CUMI-101, and found it's safe to use.
Methodology
Nine healthy volunteers were injected with 11C-CUMI-101 and imaged using PET to calculate radiation doses to various organs.
Potential Biases
Potential bias in participant selection as only healthy volunteers were included.
Limitations
The study was limited to a small sample size of healthy volunteers, which may not represent broader populations.
Participant Demographics
Nine healthy volunteers, five males and four females, average age 36 years.
Digital Object Identifier (DOI)
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