Identifying Missing Genes in Dogs
Author Information
Author(s): Derrien Thomas, Thézé Julien, Vaysse Amaury, André Catherine, Ostrander Elaine A, Galibert Francis, Hitte Christophe
Primary Institution: Institut de Génétique et Développement, CNRS UMR6061, Université de Rennes1
Hypothesis
Can comparative genomics help identify missing protein-coding genes in the domestic dog?
Conclusion
The study identified 232 new protein-coding genes in the canine genome and characterized 69 gene losses.
Supporting Evidence
- The study identified 232 new protein-coding genes in the canine genome.
- 69 gene losses were characterized as undetected genes or pseudogenes.
- The mean length of the missing genes was significantly smaller than a random set.
Takeaway
Scientists looked at dog genes and found some that were missing compared to other animals, discovering new genes and some that are no longer functional.
Methodology
The study used comparative genomics and synteny maps to identify missing genes and gene losses.
Potential Biases
The reliance on existing gene annotations may introduce bias in gene predictions.
Limitations
The study's predictions may not be exhaustive due to potential inaccuracies in sequence assembly.
Statistical Information
P-Value
6.8e-11
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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