Trends in Bacteremic Infection Due to Streptococcus pyogenes
Author Information
Author(s): Daniel M. Musher, Richard J. Hamill, Charles E. Wright, Jill E. Clarridge, Carol M. Ashton
Primary Institution: Veterans Affairs Medical Center, Houston
Hypothesis
The study investigates whether the reported increase in severe invasive infections caused by Streptococcus pyogenes reflects a true rise in incidence or is due to enhanced awareness.
Conclusion
The incidence of bacteremic infection due to S. pyogenes has not increased among veterans in Houston, Texas.
Supporting Evidence
- The number of yearly inpatient admissions decreased by 4.1% while outpatient visits increased by 33.9%.
- The rate of isolation of GAS from blood cultures remained unchanged between 1986 and 1995.
- The frequency of GAS isolation from all specimens declined significantly during the decade.
Takeaway
Doctors looked at how many people got sick from a germ called Streptococcus pyogenes over ten years and found that the number of serious infections didn't really go up.
Methodology
The study analyzed trends in bacteremic infections at the Houston Veterans Affairs Medical Center from 1986 to 1995.
Potential Biases
There is a potential for publication bias and difficulties in accurately recording cases.
Limitations
The study may not account for unrecognized changes in infection rates and relies on retrospective data.
Participant Demographics
The study population primarily consisted of middle-aged or elderly men, with about 20% under the age of 40.
Statistical Information
P-Value
0.003
Statistical Significance
p = 0.003
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