RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in Salmonella enterica serovar Typhimurium
2009
RpoE's Role in Salmonella Virulence Regulation
publication
Evidence: moderate
Author Information
Author(s): Osborne Suzanne E, Coombes Brian K
Primary Institution: McMaster University
Hypothesis
RpoE is involved in expression of genes that use the SsrB response regulator for activation.
Conclusion
RpoE fine-tunes the expression of certain virulence genes in Salmonella, which is crucial for its survival and pathogenicity.
Supporting Evidence
- RpoE deletion affects the expression of several SsrB-regulated virulence genes.
- Mutants lacking rpoE are highly attenuated for intracellular survival.
- RpoE's effects on gene expression are downstream of SsrB levels.
Takeaway
RpoE helps Salmonella bacteria control how they express genes that make them harmful, which is important for their survival inside hosts.
Methodology
The study involved creating mutants of Salmonella and analyzing the expression of virulence genes through various assays.
Limitations
The study did not explore all potential sigma factors or their interactions with SsrB-regulated genes.
Digital Object Identifier (DOI)
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