Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma
2007
Understanding Breast Lesions and Their Risks
publication
Evidence: moderate
Author Information
Author(s): Flora Zagouri, Theodoros N. Sergentanis, George C. Zografos
Primary Institution: Hippokratio Hospital, University of Athens, Athens, Greece
Hypothesis
Do molecular prognostic markers help in diagnosing and managing preinvasive breast lesions?
Conclusion
Molecular markers can improve diagnosis and treatment decisions for patients with preinvasive breast lesions.
Supporting Evidence
- ADH is a rare condition seen in 4% of benign biopsies and increases the risk of invasive breast cancer.
- DCIS constitutes 15-20% of screen-detected malignancies and has an 8-10-fold elevated risk for invasive cancer.
- Lobular neoplasia is a marker of increased risk rather than a true precursor of invasive carcinoma.
Takeaway
Some changes in breast tissue can lead to cancer, and doctors are studying certain markers to help decide how to treat these changes.
Methodology
This review article summarizes current theories and molecular markers related to preinvasive breast lesions.
Limitations
The review highlights existing controversies and the need for further research on molecular markers.
Digital Object Identifier (DOI)
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